FAQ - Revised and Reposted!

Discussion in 'Centchroman' started by MyrtleWarbler, Apr 1, 2007.


 

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  1. MyrtleWarbler

    MyrtleWarbler Super Moderator Staff Member

    This post is a revised version of a Frequently Asked Questions summary developed by myself and GreenTea about a year ago (the original version is still the leading post in the archived Centchroman Part Two thread, in the Archived Topics forum). I have made some modifications and additions, and included some updated information.

    What is Centchroman?
    Centchroman is a non-steroidal (non-hormonal) contraceptive pill developed in India more than 20 years ago, and released to the public in India as a contraceptive medication over 10 years ago. It is marketed in India under two brand names, the most common of which (among users on this board) is Saheli. The other brand name is Centron. Saheli is made by the company Hindustan Latex, which is easy to find in a web search.

    Click here to see basic information from the government-funded enterprise that developed Centchroman in India.

    Click here to see what Johns Hopkins University has to say.

    If it's not a synthetic hormone, then what is it?
    Unlike traditional hormonal contraceptives, Centchroman does not introduce synthetic hormones and altered hormonal levels into your body. Instead, Centchroman is a Selective Estrogen Receptor Modulator (SERM). SERMs are compounds which influence the way that the body's own estrogen functions at various organs in the body, sometimes enhancing estrogen's effect (estrogenic), at other times hindering or limiting estrogen's effect (anti-estrogenic). SERMs are used medically to treat breast lumps and cancer, osteoporosis after menopause, and other conditions. Centchroman is basically synonymous with an SERM called Ormeloxifene.

    To review an online slideshow about SERMs, and Ormeloxifene (centchroman) specifically, click here. Much of the content may be scientific in nature, but you should get the general message from a few summary slides in particular. This slideshow was developed by a gynecological researcher in India and presented at a conference on gynecology and obstetrics in 2002.

    How does Centchroman work?
    In a normal menstrual cycle, the uterus and ovaries work in tandem: the uterus is ready for implantation at the time ovulation occurs and for several days after. In a woman taking Centchroman, the cycle becomes out of sync: ovulation happens sooner or later than usual and the uterine lining builds up more slowly. As a result, when the egg or zygote reaches the uterus, the lining isn't built up enough for it to implant. It has also been reported that Centchroman may make the zygote move faster through the fallopian tubes, which would also interfere with successful implantation.

    Because Centchroman does not prevent ovulation, women using it are still able to detect ovulation by some methods. Some women still experience physical symptoms of ovulation, such as cramps. Women tracking basal temperatures while using Centchroman typically detect a thermal shift caused by ovulation, because the shift is driven by progesterone levels, which are not affected by Centchroman. However, most women do not describe the usual changes in cervical fluid, likely because of Centchroman's anti-estrogenic effects.

    How effective is Centchroman as birth control?
    Clinical trial users who took the dosing currently recommended, and used back-up protection for the first two or three months, experienced a failure rate of less than 2%, which is fairly comparable to traditional birth control pills. Click here to see a brief summary of the company's clinical effectiveness studies. Post-marketing surveillance of thousands more women in India has supported the reported effectiveness rates, according to the 2001 published review by Dr. M. M. Singh.

    There have been several method failure pregnancies among users in the Centchroman and Yahoo forums, although a "%" has not been calculated. It is our hope that an upcoming users survey will help shed light on the number of pregnancies that have occurred relative to the number of months/cycles covered, and also help identify any common factors among those women, if any such factors exist.

    As with any birth control method, users should consider the possibility of an unintended pregnancy when relying solely on one birth control method. Centchroman could easily be combined with other birth control methods, such as condoms, withdrawal, spermicides, and even fertility awareness methods (to a limited extent). Centchroman is a good alternative to consider for women who are unwilling or unable to utilize hormonal methods and/or who do not want the daily effort of tracking temperatures and cervical fluid (or perhaps can not do so consistently due to sleep schedules).

    How do we know it is safe to take?
    Clinical research on Centchroman took place in India from the 1960's through the 1980's, and it has been on the market there since the late 80's/early 90's. There have been no documented adverse effects to users, no reported complications from women who have used it for continuous years. Children born to mothers who were taking centchroman (and experienced a method or user failure) were followed for several years and displayed no developmental problems. Women who withdrew from the clinical trials to become pregnant conceived within the expected amount of time for people of normal fertility who are not using contraception.

    The research that has been conducted in India to document its safety and effectiveness is at least comparable to, probably in excess of, the research that first brought our familiar hormonal pill to the market.

    Additional benefits/uses of Centchroman
    Centchroman was first studied as an post-coital ("morning after") contraceptive, and shown to be effective as such. Because it can be used regularly as an ongoing contraceptive, this use was not further developed or marketed heavily, although it is a recognized use of Centchroman (click here for some info). Some users on this forum have used it as such with presumed success (no unwanted pregnancy resulted after use).

    Because of its anti-estrogenic effect in the breast, Centchroman is beneficial in reducing benign breast lumps, and has recently been found effective in the treatment of breast cancer (unpublished research, marketing being pursued in India). A doctor on the MSN board indicated she prescribes it to patients for benign lumps. More importantly, there have been many stories on this forum of users whose breast cysts and lumps improved markedly after they started Centchroman as a contraceptive.

    Centchroman is also marketed in India as a treatment for dysfunctional uterine bleeding, under the brand name Sevista.

    Does it have any side effects?
    The only clinically documented side effect is a delayed menstrual cycle. Most users will have lengthened and irregular cycles at least some of the time. For most, the cycle becomes regular again after the initial adjustment period, although it may be a slightly different schedule from before. Some users on this board have experienced additional side effects, especially during the initial months of use, which often go away within a couple months or less, such as:
    - Period becomes heavy when first pill is taken
    - Initial period(s) on Saheli heavier, more painful, and/or stopping abruptly
    - Tender breasts
    - Water retention
    - Shortened/oddly timed menstrual cycles, especially during early months
    - Hot flushes
    - Abdominal cramps (reported as minor side effect in some women in study of users with dysfunctional uterine bleeding)
    - Shorter/lighter periods
    - Hair loss
    - Excessive hair growth

    Not all new users experienced these side effects. Some users were also transitioning off of hormonal birth control, thus their experiences may be complicated with symptoms of withdrawal from synthetic hormones (such as emotional problems, yeast infecctions, acne, hair growth problems, and period irregularity). On Centchroman, cycles tend to eventually fall into a rhythm, especially once the dosage is changed from 2 pill/week to 1 pill/week (after the first three months). A very few number of users report having little to no period while on this pill.

    What does not typically happen with Centchroman is effects such as nausea, headache, weight gain, breakthrough bleeding, or mood problems, let alone anything fatal, as can happen with hormonal pills. Most of us who take Centchroman have had adverse reactions to hormones (which motivates us to try something different), but no ill effects from Centchroman. As with any birth control medication, the only way to be certain how your experience on Centchroman would be is to try it.

    Is there anyone who should not take Centchroman?
    Originally, women who have PCOS, are nursing a baby under six months, or have chronic cervicitis or cervical hyperplasia were instructed not take it, according to the package insert that comes with Saheli as it is packaged for sale in India. In an updated package insert (following additional research), Saheli is now listed as safe for lactating mothers. Furthermore, we have learned that PCOS is not a real contraindication for Centchroman, and neither is ovarian cysts. The reason for it being listed as one on the insert is that women with PCOS were excluded from the clinical trials, on the grounds that it might be impossible to tell side effects of the drug from symptoms of their disease. There is no evidence that Centchroman would cause or exacerbate PCOS or ovarian cysts. The insert also lists "severe allergic conditions," "chronic illnesses like tuberculosis, renal disease," and "recent or past history of jaundice or liver disease" as contraindications. To see a discussion on the MSN Centchroman Club that clarifies this a bit, click here.

    The current users among us include two women with histories of severe allergic reactions to many things, and one or two who had hepatitis A in childhood but no liver problems since--so, if you have a condition that you think might be a contraindication, but aren't 100% sure, you are quite welcome to post in the discussion groups (listed below) and ask--it may or may not be.

    How do I obtain Centchroman? How much does it cost?
    Because Centchroman is only available in India at the present time, users from other countries must order it from online pharmacies based in India. One popular choice is All Day Chemist, which accepts online payments and can be found with a quick web search. It may take 2-3 weeks to arrive. Pills are good for about 2 1/2 years after the date of manufacturing, thus can be ordered in a batch for a year or more. Centchroman is sold over the counter in India (as are all birth control pills), so there is no requirement for a prescription, and no legal restriction on how much they can sell to an individual customer.

    Laws in India prevent companies from selling drugs at prices in great excess of their cost. Thus, centchroman is not very expensive (especially given the exchange rate with our currencies). Most of the cost is in the shipping and handling. All Day Chemist does mark up their shipping costs substantially, but the overall cost is still very reasonable. A 12-14 month supply should cost in the neighborhood of $50 USD.

    If you are concerned about the reliability of the source, the best way to find out is from people who have used it. Several dozen of us have used All Day Chemist and found them to be reliable, and to send what they say they're sending. To check the reputation of any online pharmacy, this site is helpful: http://overseaspharmacy.com/forum/ . It's set up specifically for internet pharmacy customers to discuss their experiences with particular pharmacies.

    How do I take Centchroman?
    Centchroman is touted as a "weekly" oral contraceptive. However, for the first twelve weeks it is advised to take the pill twice per week. Backup protection is also advised (that is, barrier methods if you are sexually active), but the manufacturer does not give clear direction as to how long. Advice given in the internet discussion groups has been to use backup methods for the first two months, or even the first three months if you want to be extra safe. From the thirteenth week on, it is taken once per week.

    When initially starting, the first pill is taken on the first day of a period, and the second pill three days later. This pattern of days is repeated through the first twelve weeks. For example, Monday-Thursday, Tuesday-Friday, Wednesday-Saturday, Thursday-Sunday, Friday-Monday, Saturday-Tuesday. Starting the thirteenth week, the weekly pill is taken on the first pill day.

    Some limited additional research has suggested that slight variations on this schedule may be as effective, or possibly even more effective, but this is based on limited data. For more information, click here.

    User gds provides an interesting discussion of Centchroman and blood levels here.

    If for some reason you do not have a menstrual period (i.e. withdrawal from hormones, nursing, low body fat), keep in mind that Centchroman really must be started on the first day of your period. Since it works by altering the menstrual cycle, it may not be effective if it's not started at the beginning of one. If you are switching from hormonal birth control, starting Centchroman on your last withdrawal period is a possibility, although some users prefer to wait for a natural period.

    If this is as good as it sounds, why isn't it FDA-approved?
    The U.S. FDA only reviews research on, and subsequently approves, drugs which companies wish to bring to market. If no company in the U.S. feels it is profitable enough to obtain the patent for Centchroman, invest in research the FDA may require, and invest in the marketing (which would be substantial, for such a novel new drug), then the FDA does not get involved. Given that this pill is taken only once per week (after the initial three months), does not have side effects that would require additional drugs (such as antidepressants), and so many women are "happily" taking hormonal contraception, its potential for profit may simply not be promising enough for any company to take it on. So, it is true that this is not an "FDA-approved" drug.

    If this isn't available in my country (outside India), how can it be legal to use?
    In the United States, it is subject to the laws and regulations set forth by the FDA and by Customs, regarding its import into the country. Click here to read firsthand the FDA's compliance guidance from their Regulatory Procedures Manual, about the "personal importation" policy and enforcement of the laws that effect importation of medications through both mail and baggage.

    To be honest, the importation of Centchroman into the U.S. is not technically legal. However, neither is driving even one mile over a posted speed limit. Enforcement of the laws is at the discretion of the FDA and Customs. The FDA itself has made it clear that strict enforcement of these laws, when there is clearly no substantial threat or concern involved, is not a priority.

    It IS possible that Customs could stop your package from India at the border, determine its contents to be illegal, and send you notification that you will not be getting your package. This is the extent of any legal consequence, and has only been known to happen once or twice. In those cases, the pharmacy resent the package, and it was received with no trouble. You need not worry about being arrested, fined, or otherwise punished.

    Outside the United States, it depends on the law in that particular country. Check your country's Customs website for laws and policies on importation of foreign medications for personal use. So far, Aphrodite members have imported Centchroman to Canada, Australia, and Britain, as well as the U.S., without any problems.

    How many women on Aphrodite are currently using Centchroman?
    Discussion about Centchroman first picked up in September of 2005, when one member mentioned it, but there were no users. One American user (GreenTea) joined Aphrodite in November, and helped get the discussion going. Rather quickly, other members began using Centchroman. When users completed a pilot users survey in the fall of 2006, there were just over 50 users. It is believe this number has grown since then, although there have also been users who have quit. The length of time women in this forum community have been using Centchroman ranges from having just started, to over two years. We are all learning together as we go!

    OK, this sounds good... Where can I go to hear more about the experiences of users, and read even more information in detail?
    Aphrodite Women's Health first thread on Centchroman:
    Click here for the discussion that started it all. This topic is now closed and archived, but users considering centchroman may wish to read the entire thread for additional information and experiences.

    Aphrodite Women's Health second thread on Centchroman:
    Click here for a follow-up thread that quickly became long, and was closed and archived when Centchroman was assigned a separate subforum. Users considering centchroman may wish to read the entire thread for additional information and experiences.

    Recently Asked Questions post: Click here for a post addressing several topics in more detail, such as product durability, effects on ovulation, efficacy, etc.

    Multiply Centchroman Club (formerly MSN Centchroman Club): http://centchroman.multiply.com/ - Less discussion activity, but more users, many of whom are in India or are Indian expats, and several of whom are doctors or other medical professionals.

    Yahoo Group: http://health.groups.yahoo.com/group/centchroman/ - Less active discussion group, started by an Aphrodite member, populated mostly with users from outside of India. There is a section where you can access lengthy clinical documents published within recent years.
    Last edited by a moderator: Aug 24, 2013

     

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  2. evil lyn

    evil lyn New Member

    I'm new to the site and I am glad to find this resource...

    I never had a single reproductive issue until I turned 30 and now I have some part of my body acting crazy at least once a week.

    I have seen your posts all over this site and you seem to know a lot about this product...I have questions but can't seem to find the answers in any literature nor do i feel comfortable emailing someone in India...

    I recently was diagnosed with uterine fibroids and prescribed Aviane-28 to regulate my hormones(I started them today before I saw this site)... but I am not a fan of taking synthetic hormones and saw this product. Could I take this product with my "condition"?

     

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  3. MyrtleWarbler

    MyrtleWarbler Super Moderator Staff Member

    Well, I am not a doctor, so it wouldn't be appropriate for you to only take my word over contacting medical professionals in India. If you email saheli@hindlatex.com, you will reach Dr Nirmala Vijaykumar, a consulting gynecologist who - from what I can tell from her emails - may be of Indian descent, but is based in England. She answers product inquiries for the company, and she is really helpful. Her reply time varies a lot - sometimes really quick, sometimes not at all. I suspect my hotmail emails to her never made it, because when I emailed from yahoo, she replied right away.

    If you PM me your email address, I can send you a lengthy document about centchroman, and I will see if any other papers I have in my home files address the uterine fibroids issue. But I still suggest you email Dr. Vijaykumar.

    I hope you find a method that works for you, whether it's Centchroman or something else! I was on Aviane for a few years (Well, I was on "Alesse" and I was always on a generic, of which Aviane is one). It was really bad news for me, emotionally.

     

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  4. GreenTea

    GreenTea Super Moderator Staff Member

    Update: I have, unfortunately, just discovered that www.overseaspharmacy.com/phpBB/ no longer exists. I did a quick Google search to see if the site's out there with a new URL, and haven't found anything. Still searching for other discussion forums about overseas pharmacies, but haven't found anything navigable yet.
    Last edited by a moderator: Aug 24, 2013

     

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  5. BrinnyB

    BrinnyB New Member

    i just found this post and it sounds amazing!

    i just recently got off hormonal BC pills because i was getting all kinds of ocd, anxiety/ panic attakcs, and depression.
    i woudl like to kno if this helps with the regulating of your cycle and overall mind and whatnot, cause i am dying to get back to my normal self again.

    i was just wondering if you might know of an online pharmacist that i might be able to get in tounch with.

     

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  6. MyrtleWarbler

    MyrtleWarbler Super Moderator Staff Member

    Brinny...

    Most of us order the stuff from alldaychemist.com, however I wouldn't count on them for product info and support.

    You could go to the link for the company, Hindustan Latex... You can send messages with "product inquiries"... If it's still the same woman, it's a really helpful consulting gynecologist who handles the questions. You should be able to email her directly at saheli@hindlatex.com (I think that's it).

    PM me your email address, if you want, and I'll send you a lengthy and thorough document with much more info about centchroman and the research behind it.

    Reports of people from this forum having emotional problems are very rare. Have a look at the link of survey results (I really need to revisit that, as I stated I would...). Getting back to normal just off HBC can take some time, emotionally.

    I had pretty regular cycles on Saheli. A little longer than "normal" but turns out they are still about the same several months off of it (trying for a baby now). But some women had irregular cycles, long cycles, skipped periods, etc. In fact, I would say that for some women, that irregularity (and the uncertainty/concern that go with it) were factors against their satisfaction with Saheli. As with any pill, you just don't know how it will be unless you try.

    It is a very unusual choice, and you should read everything you can - the document I can send, the survey results and summary, etc - before deciding. But there are happy long term users... this forum has gotten quiet, b/c everyone has either tried and decided it's not for them, or has been using it happily with no trouble and thus no reason to post!

     

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  7. GreenTea

    GreenTea Super Moderator Staff Member

    At long last, good news, everyone: the overseas pharmacy forum is back! Its discussion board, much shorter than the old, is now found here: http://overseaspharmacy.com/forum/

    I briefly skimmed it and saw no mention of All Day Chemist, but the previous overseas pharmacy forum did give it a good rep.
    Last edited by a moderator: Aug 24, 2013

     

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  8. liljunebug

    liljunebug New Member

    Thanks for the great info!

    [​IMG]
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  9. simon

    simon New Member

    Hey really helpful information about health

     

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