Early treatment with the diabetes drug metformin may prevent or delay the development of polycystic ovary syndrome (PCOS) in adolescence, according to a study published in the Journal of Clinical Endocrinology & Metabolism.
PCOS affects an estimated 10 percent of women of childbearing age and is the most common cause of infertility, according to The Hormone Foundation.
"PCOS often presents in adolescence, with irregular menstrual cycles, acne, or too much body hair," said the study's senior author, Lourdes Ibáñez, at the University of Barcelona in Spain. "But we believe the critical years for PCOS development may be during childhood and puberty when excessive amounts of fat are stored. That excessive weight gain overexposes the ovaries to insulin, causing them to stop ovulating and start releasing male hormones, resulting in PCOS."
In this study of 38 girls with low birth-weight and early puberty, the researchers compared the efficacy of early versus late metformin treatment to prevent adolescent PCOS. A group of 19 8-year-old girls were treated with daily doses of metformin for four years. A second group of 19 girls waited five years before they began receiving daily doses of metformin at age 13 and then continued treatment for only one year. The researchers found that early metformin therapy prevented or delayed the development of hirsutism, androgen excess and PCOS more effectively than late metformin treatment.
"Metformin... may have the capacity to reprogram metabolism toward less abdominal and liver fat," Ibáñez concluded. "In the years ahead, the focus of attention should shift from late treatment of PCOS and its complications, toward the early and large-scale prevention of PCOS, with measures such as diet, exercise and metformin in young girls."
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Source: The Endocrine Society